There are a number of troubleshooting methods you can take if QuickBooks Desktop is refusing to open. Restarting your computer and making sure your system satisfies QuickBooks' basic requirements should be your first steps. Look for software upgrades because out-of-date versions can lead to issues. In order to resolve any possible permission difficulties, run QuickBooks as administrator. Use the "Verify and Rebuild Data" tool to look for file corruption if the software still won't open. To find out if the problem is unique to one organization, you can also try opening a different file.